UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System

Overview of UV15X-6Med-2

UV15X-6Med-2 is a one-component, medium-viscosity UV-curable system that offers high flexibility, toughness, abrasion resistance, and strong adhesion to substrates including glass, polycarbonates, acrylics, plastics, metals, and rubbers. It cures within 10-30 seconds under 320-365 nm UV light and provides excellent toughness, optical clarity, and electrical insulation. Its biocompatibility (passes USP Class VI and ISO 10993-5 cytotoxicity testing) and water resistance make it ideal for encapsulating implantable devices like wireless vagus nerve stimulation systems.

Application

Vagus nerve stimulation (VNS) has been investigated for treating conditions like epilepsy and drug-resistant depression, but conventional open-loop systems require trained personnel to manually adjust parameters. To overcome these limitations, researchers at UCLA developed a closed-loop, fully-automated wireless VNS (FAW-VNS) system with a biocompatible, miniaturized, wirelessly-powered implant. It featured a handheld power and communication device, a heart rate sensing patch, and a central control unit for dynamically adjusting stimulation in real time. To ensure the long-term safety, reliability, and functionality of the FAW-VNS within the body, the authors encapsulated it with UV15X-6Med-2 to provide a biocompatible barrier that prevented tissue damage while protecting sensitive electronics from moisture and corrosion.

To read about the key parameters, requirements, and results, please download the full case study.

Download full case study

References

Mathews, R.P., Habibagahi, I., Jafari Sharemi, H. et al. A closed loop fully automated wireless vagus nerve stimulation system. Sci Rep 15, 27856 (2025). https://doi.org/10.1038/s41598-025-11159-8